All you've got to do is pick the system for creating your character sheet and start filling out the corresponding fields. Depending on the game you may also be able to pick from different kinds of character creation ... or just fill in the sheet however you want, period.
Besides creating character sheets, Hero Lab has a good selection of tools aimed exclusively at game directors. Thanks to these extras you can quickly create entries for NPCs or take a look at the stats for any monster.
Hero Lab is a very useful program for any roleplay gamer. And it should be particularly useful for game directors, who'll find lots of interesting tools in it.